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The clinical utility of cfRNA for disease detection and surveillance: A proof of concept study in non‐small cell lung cancer

Metzenmacher, Martin ; Hegedüs, Balazs ; Forster, Jan ; Schramm, Alexander ; Horn, Peter A. ; Klein, Christoph A. ; Bielefeld, Nicola ; Ploenes, Till ; Aigner, Clemens ; Siveke, Jens T. ; Schuler, Martin ; Lueong, Smiths S.


Background CT scans are used in routine clinical practice for the diagnosis and treatment surveillance of non-small cell lung cancer (NSCLC). However, more sensitive methods are desirable. Liquid biopsy analyses of RNA and DNA can offer more sensitive diagnostic approaches. Cell-free RNA (cfRNA) has been described in several malignancies, but its clinical utility has not previously been explored. ...


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