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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis

te Boekhorst, Veronika ; Jiang, Liying ; Mählen, Marius ; Meerlo, Maaike ; Dunkel, Gina ; Durst, Franziska C. ; Yang, Yanjun ; Levine, Herbert ; Burgering, Boudewijn M.T. ; Friedl, Peter



Abstract

Hypoxia, through hypoxia inducible factor (HIF), drives cancer cell invasion and metastatic progression in various cancer types. In epithelial cancer, hypoxia induces the transition to amoeboid cancer cell dissemination, yet the molecular mechanisms, relevance for metastasis, and effective intervention to combat hypoxia-induced amoeboid reprogramming remain unclear. Here, we identify calpain-2 as ...

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