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Ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma: a multicenter study of the prospective skin cancer registry ADOREG

Glutsch, Valerie ; Schummer, Patrick ; Kneitz, Hermann ; Gesierich, Anja ; Goebeler, Matthias ; Klein, Detlef ; Posch, Christian ; Gebhardt, Christoffer ; Haferkamp, Sebastian ; Zimmer, Lisa ; Becker, Jürgen C ; Leiter, Ulrike ; Weichenthal, Michael ; Schadendorf, Dirk ; Ugurel, Selma ; Schilling, Bastian



Abstract

Merkel cell carcinoma is a rare, highly aggressive skin cancer with neuroendocrine differentiation. Immune checkpoint inhibition has significantly improved treatment outcomes in metastatic disease with response rates to programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) inhibition of up to 62%. However, primary and secondary resistance to PD-1/PD-L1 inhibition remains a ...

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