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Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

Rodenburg, Lisa W. ; Delpiano, Livia ; Railean, Violeta ; Centeio, Raquel ; Pinto, Madalena C. ; Smits, Shannon M. A. ; van der Windt, Isabelle S. ; van Hugten, Casper F. J. ; van Beuningen, Sam F. B. ; Rodenburg, Remco N. P. ; van der Ent, Cornelis K. ; Amaral, Margarida D. ; Kunzelmann, Karl ; Gray, Michael A. ; Beekman, Jeffrey M. ; Amatngalim, Gimano D.



Zusammenfassung

Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which impairs airway epithelial ion and fluid secretion. New CFTR modulators that restore mutant CFTR function have been recently approved for a large group of people with CF (pwCF), but similar to 19% of pwCF cannot benefit ...

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