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A monocyte–leptin–angiogenesis pathway critical for repair post-infection

Kratofil, Rachel M. ; Shim, Hanjoo B. ; Shim, Raymond ; Lee, Woo Yong ; Labit, Elodie ; Sinha, Sarthak ; Keenan, Catherine M. ; Surewaard, Bas G. J. ; Noh, Ji Yeon ; Sun, Yuxiang ; Sharkey, Keith A. ; Mack, Matthias ; Biernaskie, Jeff ; Deniset, Justin F. ; Kubes, Paul



Abstract

During infection, inflammatory monocytes are thought to be key for bacterial eradication, but this is hard to reconcile with the large numbers of neutrophils that are recruited for each monocyte that migrates to the afflicted tissue, and the much more robust microbicidal functions of the neutrophils. However, unlike neutrophils, monocytes have the capacity to convert to situationally specific ...

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