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DNA methylation patterns reflect individual's lifestyle independent of obesity

Klemp, Ireen ; Hoffmann, Anne ; Müller, Luise ; Hagemann, Tobias ; Horn, Kathrin ; Rohde‐Zimmermann, Kerstin ; Tönjes, Anke ; Thiery, Joachim ; Löffler, Markus ; Burkhardt, Ralph ; Böttcher, Yvonne ; Stumvoll, Michael ; Blüher, Matthias ; Krohn, Knut ; Scholz, Markus ; Baber, Ronny ; Franks, Paul W ; Kovacs, Peter ; Keller, Maria



Abstract

Objective Obesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population-based cohort from Germany. Research design and methods Lifestyle scores (LS) based on diet, physical activity, smoking and alcohol intake were ...

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