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Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors

Lenti, Elisa ; Genovese, Luca ; Bianchessi, Silvia ; Maurizio, Aurora ; Sain, Simona Baghai ; di Lillo, Alessia ; Mattavelli, Greta ; Harel, Itamar ; Bernassola, Francesca ; Hehlgans, Thomas ; Pfeffer, Klaus ; Crosti, Mariacristina ; Abrignani, Sergio ; Evans, Sylvia M. ; Sitia, Giovanni ; Guimarães-Camboa, Nuno ; Russo, Vincenzo ; van de Pavert, Serge A. ; Garcia-Manteiga, Jose Manuel ; Brendolan, Andrea



Abstract

Lymph node (LN) stromal cells play a crucial role in LN development and in supporting adaptive immune responses. However, their origin, differentiation pathways, and transcriptional programs are still elusive. Here, we used lineage-tracing approaches and single-cell transcriptome analyses to determine origin, transcriptional profile, and composition of LN stromal and endothelial progenitors. Our ...

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