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Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

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Haupt, Luis Peter ; Rebs, Sabine ; Maurer, Wiebke ; Hübscher, Daniela ; Tiburcy, Malte ; Pabel, Steffen ; Maus, Andreas ; Köhne, Steffen ; Tappu, Rewati ; Haas, Jan ; Li, Yun ; Sasse, Andre ; Santos, Celio C. X. ; Dressel, Ralf ; Wojnowski, Leszek ; Bunt, Gertrude ; Möbius, Wiebke ; Shah, Ajay M. ; Meder, Benjamin ; Wollnik, Bernd ; Sossalla, Samuel ; Hasenfuss, Gerd ; Streckfuss-Bömeke, Katrin
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Date of publication of this fulltext: 29 Feb 2024 13:01


Cancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and to examine whether doxorubicin (DOX)-treated ACT-iPSC cardiomyocytes (CM) can recapitulate the clinical ...


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