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Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids

Ruiz de Gauna, Mikel ; Biancaniello, Francesca ; González‐Romero, Francisco ; Rodrigues, Pedro M. ; Lapitz, Ainhoa ; Gómez‐Santos, Beatriz ; Olaizola, Paula ; Di Matteo, Sabina ; Aurrekoetxea, Igor ; Labiano, Ibone ; Nieva‐Zuluaga, Ane ; Benito‐Vicente, Asier ; Perugorria, María J. ; Apodaka‐Biguri, Maider ; Paiva, Nuno A. ; Sáenz de Urturi, Diego ; Buqué, Xabier ; Delgado, Igotz ; Martín, César ; Azkargorta, Mikel ; Elortza, Felix ; Calvisi, Diego F. ; Andersen, Jesper B. ; Alvaro, Domenico ; Cardinale, Vincenzo ; Bujanda, Luis ; Banales, Jesús M. ; Aspichueta, Patricia



Abstract

Background and Aims Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with a dismal prognosis. We investigated if lipid metabolism is disrupted in CCA and its role in tumor proliferation. Approach and Results The in vitro and in vivo tumorigenic capacity of five human CCA cell lines was analyzed. Proteome, lipid content, and metabolic fluxes were evaluated in CCA cells ...

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