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Convalescent plasma treatment for SARS-CoV-2 infected high-risk patients: a matched pair analysis to the LEOSS cohort

Freise, Noemi F. ; Gliga, Smaranda ; Fischer, Johannes ; Lübke, Nadine ; Lutterbeck, Matthias ; Schöler, Miriam ; Bölke, Edwin ; Orth, Hans Martin ; Feldt, Torsten ; Roemmele, Christoph ; Wilke, Dominik ; Schneider, Jochen ; Wille, Kai ; Hohmann, Christian ; Strauss, Richard ; Hower, Martin ; Ruf, Andreas ; Schubert, Joerg ; Isberner, Nora ; Stecher, Melanie ; Pilgram, Lisa ; Vehreschild, Jörg J. ; de With, Katja ; Spinner, Christoph ; Lanznaster, Julia ; Beutel, Gernot ; Jung, Norma ; Göpel, Siri ; Westhoff, Timm ; Hohenstein, Bernd ; Rothfuss, Katja ; Rieg, Siegbert ; Ruethrich, Maria Madeleine ; Rupp, Jan ; Hanses, Frank ; Luedde, Tom ; Jensen, Björn



Abstract

Establishing the optimal treatment for COVID-19 patients remains challenging. Specifically, immunocompromised and pre-diseased patients are at high risk for severe disease course and face limited therapeutic options. Convalescent plasma (CP) has been considered as therapeutic approach, but reliable data are lacking, especially for high-risk patients. We performed a retrospective analysis of 55 ...

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