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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

Hua, Yichao ; Vella, Gerlanda ; Rambow, Florian ; Allen, Elizabeth ; Antoranz Martinez, Asier ; Duhamel, Marie ; Takeda, Akira ; Jalkanen, Sirpa ; Junius, Steffie ; Smeets, Ann ; Nittner, David ; Dimmeler, Stefanie ; Hehlgans, Thomas ; Liston, Adrian ; Bosisio, Francesca Maria ; Floris, Giuseppe ; Laoui, Damya ; Hollmén, Maija ; Lambrechts, Diether ; Merchiers, Pascal ; Marine, Jean-Christophe ; Schlenner, Susan ; Bergers, Gabriele


The lack of T cell infiltrates is a major obstacle to effective immunotherapy in cancer. Conversely, the forma-tion of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs), which are the local site of humoral and cellular immune responses against cancers, is associated with good prognosis, and they have recently been detected in immune checkpoint blockade (ICB)-responding patients. ...


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