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The rate of cholangiocarcinoma in Caroli Disease A German multicenter study

Fard-Aghaie, Mohammad H. ; Makridis, Georgios ; Reese, Tim ; Feyerabend, Bernd ; Wagner, Kim C. ; Schnitzbauer, Andreas ; Bechstein, Wolf O. ; Oldhafer, Felix ; Kleine, Moritz ; Klempnauer, Jürgen ; Rolinger, Jens ; Nadalin, Silvio ; Königsrainer, Alfred ; Vassos, Nikolaos ; Grützmann, Robert ; Benkö, Tamas ; Paul, Andreas ; Li, Jun ; Fischer, Lutz ; Beaumont, Katharina ; Nüssler, Natascha ; Fahrner, René ; Settmacher, Utz ; Fichtner-Feigl, Stefan ; Schöning, Wenzel ; Pratschke, Johann ; Eckhoff, Jennifer A. ; Wahba, Roger ; Bruns, Christiane ; Bernsmeier, Alexander ; Braun, Felix ; Becker, Thomas ; Lurje, Georg ; Neumann, Ulf P. ; Dohmen, Jonas ; Manekeller, Steffen ; Kalff, Jörg C. ; Mehrabi, Arianeb ; Büchler, Markus W. ; Lang, Sven A. ; Schlitt, Hans J. ; Tripke, Verena ; Lang, Hauke ; Oldhafer, Karl J.



Abstract

Background: Caroli Disease (CD) and Caroli Syndrome (CS) are rare disorders presenting with dilation of the intrahepatic bile ducts. CD/CS are associated with cholangiocarcinoma (CCA). However, the true incidence of CCA is still unclear, although it may serve as an indication for surgery. In this paper, we analyzed (I) the incidence of CCA in German centers, (II) reviewed our single center ...

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