; Galimard, Jacques-Emmanuel ; Labopin, Myriam ; Bornhäuser, Martin ; Stelljes, Matthias ; Finke, Jürgen
; Ganser, Arnold
; Einsele, Herman ; Kröger, Nicolaus ; Brecht, Arne ; Bethge, Wolfgang ; Edinger, Matthias ; Kulagin, Aleksandr
; Passweg, Jakob ; Blau, Igor Wolfgang ; Elmaagacli, Ahmet ; Schäfer-Eckart, Kerstin ; Platzbecker, Uwe ; Schroeder, Thomas ; Bunjes, Donald ; Tischer, Johanna ; Martin, Sonja ; Spyridonidis, Alexandros ; Giebel, Sebastian ; Savani, Bipin ; Mohty, Mohamad 
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Clinical Cancer Research | ||||
| Publisher: | AMER ASSOC CANCER RESEARCH | ||||
| Place of Publication: | PHILADELPHIA | ||||
| Volume: | 28 | ||||
| Number of Issue or Book Chapter: | 19 | ||||
| Page Range: | pp. 4258-4266 | ||||
| Date: | 2022 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) | ||||
| Identification Number: |
| ||||
| Keywords: | VERSUS-HOST-DISEASE; RETROSPECTIVE ANALYSIS; AML; SURVIVAL; RELAPSE; ADULTS; BLOOD; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 57751 |
Abstract
Purpose: We evaluated outcomes of unrelated transplantation for primary refractory/relapsed (ref/rel) acute myeloid leukemia (AML), comparing two cohorts according to the year of transplant, 2000-2009 and 2010-2019.Patients and Methods: Multivariable analyses were performed using the Cox proportional-hazards regression model.Results: 3,430 patients were included; 876 underwent a trans-plant ...

Abstract
Purpose: We evaluated outcomes of unrelated transplantation for primary refractory/relapsed (ref/rel) acute myeloid leukemia (AML), comparing two cohorts according to the year of transplant, 2000-2009 and 2010-2019.Patients and Methods: Multivariable analyses were performed using the Cox proportional-hazards regression model.Results: 3,430 patients were included; 876 underwent a trans-plant between 2000-2009 and 2554 in 2010-2019. Median follow-up was 8.7 (95% CI, 7.8-9.4) and 3.4 (95% CI, 3.1-3.6) years (P < 0.001). Median age was 52 (18-77) and 56 (18-79) years (P > 0.0001); 45.5% and 55.5% had refractory AML while 54.5% and 44.5% had relapsed AML. Conditioning was myeloablative in 60% and 52%, respectively. Neutrophil recovery and day 100 incidence of acute and 2-year incidence of chronic graft-versus-host disease (GvHD) were similar between the two periods. Two-year relapse incidence was higher for patients undergoing transplant in the 2000-2009 period versus those undergoing transplant in 2010- 2019: 50.2% versus 45.1% (HR, 0.85; 95% CI, 0.74-0.97; P = 0.002). Leukemia-free survival; overall survival; and GvHD-free, relapse-free survival were lower for the 2000-2009 period: 26% versus 32.1% (HR, 0.87; 95% CI, 0.78-0.97; P = 0.01), 32.1% versus 38.1% (HR, 0.86; 95% CI, 0.77-0.96; P = 0.01), and 21.5% versus 25.3% (HR, 0.89; 95% CI, 0.81-0.99; P = 0.03), respectively. Two-year non-relapse mortality was not significantly different (23.8% vs. 23.7%; HR, 0.91; 95% CI, 0.76-1.11; P = 0.34).Conclusions: Outcome of unrelated transplantation for patients with ref/rel AML has improved in the last two decades, rescuing about one third of the patients.
Metadata last modified: 29 Feb 2024 13:02
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