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Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry

Stefan, Norbert ; Sippel, Katrin ; Heni, Martin ; Fritsche, Andreas ; Wagner, Robert ; Jakob, Carolin E. M. ; Preißl, Hubert ; von Werder, Alexander ; Khodamoradi, Yascha ; Borgmann, Stefan ; Rüthrich, Maria Madeleine ; Hanses, Frank ; Haselberger, Martina ; Piepel, Christiane ; Hower, Martin ; vom Dahl, Jürgen ; Wille, Kai ; Römmele, Christoph ; Vehreschild, Janne ; Stecher, Melanie ; Solimena, Michele ; Roden, Michael ; Schürmann, Annette ; Gallwitz, Baptist ; Hrabe de Angelis, Martin ; Ludwig, David S. ; Schulze, Matthias B. ; Jensen, Bjoern Erik Ole ; Birkenfeld, Andreas L.



Abstract

Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on ...

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