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The impact of TP53 co-mutations and immunologic microenvironment on outcome of lung cancer with EGFR exon 20 insertions

Christopoulos, Petros ; Kluck, Klaus ; Kirchner, Martina ; Lüders, Heike ; Roeper, Julia ; Falkenstern-Ge, Roger-Fei ; Szewczyk, Marlen ; Sticht, Florian ; Saalfeld, Felix C. ; Wesseler, Claas ; Hackanson, Björn ; Dintner, Sebastian ; Faehling, Martin ; Kuon, Jonas ; Janning, Melanie ; Kauffmann-Guerrero, Diego ; Kazdal, Daniel ; Kurz, Sylke ; Eichhorn, Florian ; Bozorgmehr, Farastuk ; Shah, Rajiv ; Tufman, Amanda ; Wermke, Martin ; Loges, Sonja ; Brueckl, Wolfgang M. ; Schulz, Christian ; Misch, Daniel ; Frost, Nikolaj ; Kollmeier, Jens ; Reck, Martin ; Griesinger, Frank ; Grohé, Christian ; Hong, Jin-Liern ; Lin, Huamao M. ; Budczies, Jan ; Stenzinger, Albrecht ; Thomas, Michael



Abstract

Background: EGFR exon20 insertions (ex20ins) are targeted by novel compounds in non-small-cell lung cancer (NSCLC). However, data about outcome under conventional therapies and the influence of molecular features are scarce. Patients and methods: We retrospectively analysed 118 patients with evaluation of radiologic response based on RECIST v1.1. TP53 status was available for 88 cases. Results: ...

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