Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL – long-term follow-up from the prospective ALL-SCT 2003 trial - University of Regensburg Publication Server

URN to cite this document:: urn:nbn:de:bvb:355-epub-577667
DOI to cite this document:: 10.5283/epub.57766

Eichinger, Anna

; Poetschger, Ulrike ; Glogova, Evgenia ; Bader, Peter ; Basu, Oliver ; Beier, Rita ; Burkhardt, Birgit ; Classen, Carl-Friedrich ; Claviez, Alexander

; Corbacioglu, Selim

; Deubzer, Hedwig E.

; Greil, Johann ; Gruhn, Bernd ; Güngör, Tayfun ; Kafa, Kinan ; Kühl, Jörn-Sven ; Lang, Peter ; Lange, Bjoern Soenke ; Meisel, Roland ; Müller, Ingo ; Sauer, Martin G. ; Schlegel, Paul-Gerhardt ; Schulz, Ansgar ; Stachel, Daniel ; Strahm, Brigitte ; Wawer, Angela ; Peters, Christina ; Albert, Michael H.

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Date of publication of this fulltext: 29 Feb 2024 13:02

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Abstract

Total body irradiation (TBI)-based conditioning is associated with superior leukemia-free survival in children with ALL undergoing HSCT. However, the risk for subsequent malignant neoplasms (SMN) remains a significant concern. We analyzed 705 pediatric patients enrolled in the prospective ALL-SCT-BFM-2003 trial and its subsequent registry. Patients >2 years received conditioning with TBI 12 ...