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Multicenter evaluation of neoadjuvant and induction gemcitabine–carboplatin versus gemcitabine–cisplatin followed by radical cystectomy for muscle-invasive bladder cancer

Einerhand, Sarah M. H. ; Black, Anna J. ; Zargar, Homayoun ; Fairey, Adrian S. ; Dinney, Colin P. ; Mir, Maria C. ; Krabbe, Laura-Maria ; Cookson, Michael S. ; Jacobson, Niels-Erik ; Montgomery, Jeffrey S. ; Vasdev, Nikhil ; Yu, Evan Y. ; Xylinas, Evanguelos ; Kassouf, Wassim ; Dall’Era, Marc A. ; Sridhar, Srikala S. ; McGrath, Jonathan S. ; Aning, Jonathan ; Shariat, Shahrokh F. ; Wright, Jonathan L. ; Thorpe, Andrew C. ; Morgan, Todd M. ; Holzbeierlein, Jeff M. ; Bivalacqua, Trinity J. ; North, Scott ; Barocas, Daniel A. ; Lotan, Yair ; Grivas, Petros ; Garcia, Jorge A. ; Stephenson, Andrew J. ; Shah, Jay B. ; Daneshmand, Siamak ; Zargar-Shoshtari, Kamran ; Spiess, Philippe E. ; van Rhijn, Bas W. G. ; Black, Peter C. ; Mertens, Laura S.



Abstract

Purpose Cisplatin-based chemotherapy followed by radical cystectomy (RC) is recommended in patients with muscle-invasive bladder cancer (MIBC). However, up to 50% of patients are cisplatin ineligible. The aim of this study was to compare clinical outcomes after >= 3 cycles of preoperative gemcitabine-carboplatin (gem-carbo) versus gemcitabine-cisplatin (gem-cis). Methods We identified 1865 ...

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