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Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

Li, Shuai ; Silvestri, Valentina ; Leslie, Goska ; Rebbeck, Timothy R. ; Neuhausen, Susan L. ; Hopper, John L. ; Nielsen, Henriette Roed ; Lee, Andrew ; Yang, Xin ; McGuffog, Lesley ; Parsons, Michael T. ; Andrulis, Irene L. ; Arnold, Norbert ; Belotti, Muriel ; Borg, Åke ; Buecher, Bruno ; Buys, Saundra S. ; Caputo, Sandrine M. ; Chung, Wendy K. ; Colas, Chrystelle ; Colonna, Sarah V. ; Cook, Jackie ; Daly, Mary B. ; de la Hoya, Miguel ; de Pauw, Antoine ; Delhomelle, Hélène ; Eason, Jacqueline ; Engel, Christoph ; Evans, D. Gareth ; Faust, Ulrike ; Fehm, Tanja N. ; Fostira, Florentia ; Fountzilas, George ; Frone, Megan ; Garcia-Barberan, Vanesa ; Garre, Pilar ; Gauthier-Villars, Marion ; Gehrig, Andrea ; Glendon, Gord ; Goldgar, David E. ; Golmard, Lisa ; Greene, Mark H. ; Hahnen, Eric ; Hamann, Ute ; Hanson, Helen ; Hassan, Tiara ; Hentschel, Julia ; Horvath, Judit ; Izatt, Louise ; Janavicius, Ramunas ; Jiao, Yue ; John, Esther M. ; Karlan, Beth Y. ; Kim, Sung-Won ; Konstantopoulou, Irene ; Kwong, Ava ; Laugé, Anthony ; Lee, Jong Won ; Lesueur, Fabienne ; Mebirouk, Noura ; Meindl, Alfons ; Mouret-Fourme, Emmanuelle ; Musgrave, Hannah ; Ngeow Yuen Yie, Joanne ; Niederacher, Dieter ; Park, Sue K. ; Pedersen, Inge Sokilde ; Ramser, Juliane ; Ramus, Susan J. ; Rantala, Johanna ; Rashid, Muhammad U. ; Reichl, Florian ; Ritter, Julia ; Rump, Andreas ; Santamariña, Marta ; Saule, Claire ; Schmidt, Gunnar ; Schmutzler, Rita K. ; Senter, Leigha ; Shariff, Saba ; Singer, Christian F. ; Southey, Melissa C. ; Stoppa-Lyonnet, Dominique ; Sutter, Christian ; Tan, Yen ; Teo, Soo Hwang ; Terry, Mary Beth ; Thomassen, Mads ; Tischkowitz, Marc ; Toland, Amanda E. ; Torres, Diana ; Vega, Ana ; Wagner, Sebastian A. ; Wang-Gohrke, Shan ; Wappenschmidt, Barbara ; Weber, Bernhard H. F. ; Yannoukakos, Drakoulis ; Spurdle, Amanda B. ; Easton, Douglas F. ; Chenevix-Trench, Georgia ; Ottini, Laura ; Antoniou, Antonis C.



Abstract

PURPOSE To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. METHODS We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 ...

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