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Multi‐ancestry genome‐wide association study of asthma exacerbations

Herrera‐Luis, Esther ; Ortega, Victor E. ; Ampleford, Elizabeth J. ; Sio, Yang Yie ; Granell, Raquel ; de Roos, Emmely ; Terzikhan, Natalie ; Vergara, Ernesto Elorduy ; Hernandez‐Pacheco, Natalia ; Perez‐Garcia, Javier ; Martin‐Gonzalez, Elena ; Lorenzo‐Diaz, Fabian ; Hashimoto, Simone ; Brinkman, Paul ; Jorgensen, Andrea L. ; Yan, Qi ; Forno, Erick ; Vijverberg, Susanne J. ; Lethem, Ryan ; Espuela‐Ortiz, Antonio ; Gorenjak, Mario ; Eng, Celeste ; González‐Pérez, Ruperto ; Hernández‐Pérez, José M. ; Poza‐Guedes, Paloma ; Sardón, Olaia ; Corcuera, Paula ; Hawkins, Greg A. ; Marsico, Annalisa ; Bahmer, Thomas ; Rabe, Klaus F. ; Hansen, Gesine ; Kopp, Matthias Volkmar ; Rios, Raimon ; Cruz, Maria Jesus ; González‐Barcala, Francisco‐Javier ; Olaguibel, José María ; Plaza, Vicente ; Quirce, Santiago ; Canino, Glorisa ; Cloutier, Michelle ; del Pozo, Victoria ; Rodriguez‐Santana, Jose R. ; Korta‐Murua, Javier ; Villar, Jesús ; Potočnik, Uroš ; Figueiredo, Camila ; Kabesch, Michael ; Mukhopadhyay, Somnath ; Pirmohamed, Munir ; Hawcutt, Daniel B. ; Melén, Erik ; Palmer, Colin N. ; Turner, Steve ; Maitland‐van der Zee, Anke H. ; von Mutius, Erika ; Celedón, Juan C. ; Brusselle, Guy ; Chew, Fook Tim ; Bleecker, Eugene ; Meyers, Deborah ; Burchard, Esteban G. ; Pino‐Yanes, Maria



Abstract

Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this ...

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