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Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor

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Promm, Martin ; Otto, Wolfgang ; Götz, Stefanie ; Burger, Maximilian ; Müller, Karolina ; Rubenwolf, Peter ; Neuhuber, Winfried L. ; Rösch, Wolfgang H.
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Date of publication of this fulltext: 08 Mar 2024 06:54

This publication is part of the DEAL contract with Springer.


Purpose An overexpression of nerve growth factor (NGF) in the urothelium is discussed to lead to neuronal hyperinnervation of the bladder detrusor. The aim was to assess the sensory and sympathetic innervation of the detrusor in unclosed exstrophic bladders patients with known overexpression of NGF in the urothelium. Methods Full-thickness bladder biopsies were prospectively obtained from 34 ...


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