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Covalent and Visible-Light Photoswitchable Derivatives of the Potent Synthetic Opioid Isotonitazene and Other Nitazenes

Lahmy, Ranit ; Hübner, Harald ; Gmeiner, Peter ; König, Burkhard


This publication is part of the DEAL contract with Wiley.


Abstract

Isotonitazene belongs to a potent class of m-opioid receptor (µOR) ligands, known as nitazenes. The lack of knowledge surrounding this agonist and others in its class has sparked thorough re-investigations. To aid in these investigations, the purportedly covalent yet underexplored nitazene BIT was biochemically re-evaluated in this work, along with a newly synthesized analogue, Iso-BIT. Moreover, ...

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