Covalent and Visible-Light Photoswitchable Derivatives of the Potent Synthetic Opioid Isotonitazene and Other Nitazenes

URN to cite this document:: urn:nbn:de:bvb:355-epub-579163
DOI to cite this document:: 10.5283/epub.57916

Lahmy, Ranit

; Hübner, Harald

; Gmeiner, Peter

; König, Burkhard

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Mar 2024 05:51

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Abstract

Isotonitazene belongs to a potent class of m-opioid receptor (µOR) ligands, known as nitazenes. The lack of knowledge surrounding this agonist and others in its class has sparked thorough re-investigations. To aid in these investigations, the purportedly covalent yet underexplored nitazene BIT was biochemically re-evaluated in this work, along with a newly synthesized analogue, Iso-BIT. Moreover, ...