Secondary solid malignancies and precancerous lesions after allogeneic hematopoietic stem cell transplantation using non-total body irradiation-based conditioning in acute myeloid leukemia

URN to cite this document:

urn:nbn:de:bvb:355-epub-579886 Copy

DOI to cite this document:

10.5283/epub.57988 Copy

Gruber, Isabella ; Appel, Katharina ; Edinger, Matthias ; Koelbl, Oliver ; Wolff, Daniel

License: Creative Commons Attribution 4.0 PDF - Published Version (686kB)

Date of publication of this fulltext: 26 Mar 2024 10:15

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Details

Item type:	Article
Open Access Type:	DEAL (Springer Gold)
Journal or Publication Title:	Journal of Cancer Research and Clinical Oncology
Publisher:	Springer
Volume:	150
Number of Issue or Book Chapter:	3
Date:	22 March 2024
Institutions:	Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Strahlentherapie
Identification Number:	Value Type 10.1007/s00432-024-05679-5 DOI
Keywords:	Allogeneic-hematopoietic stem cell transplantation · Secondary solid malignancies · Graft-versus-host disease · Chemotherapy-only conditioning · Acute myeloid leukemia
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	57988

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Abstract

Introduction Long-term survivors have an increased risk of developing secondary solid malignancies (SSMs) after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) with graft-versus-host disease (GVHD) potentially modulating these risks. Methods This retrospective study analyzed the cumulative incidences of SSMs after chemotherapy-based conditioning for allo-HSCT patients with acute ...

Abstract

Introduction
Long-term survivors have an increased risk of developing secondary solid malignancies (SSMs) after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) with graft-versus-host disease (GVHD) potentially modulating these risks.
Methods
This retrospective study analyzed the cumulative incidences of SSMs after chemotherapy-based conditioning for allo-HSCT patients with acute myeloid leukemia (n = 266) transplanted at the University Hospital Regensburg between 1999 and 2016.
Results
The median follow-up was 11.4 years (Interquartile range, 9.0–14.9). The 100-day cumulative incidence of grade II-IV acute GVHD (aGVHD) was 44.4% [95% CI (38.3, 50.2)], while the 5-year cumulative incidence of chronic GVHD (cGVHD, requiring systemic immunosuppression) was 36.9% [95% CI (31.1, 42.6)]. The cumulative incidences of secondary squamous cell carcinomas (SCCs) at 10 and 15 years were 4.2% [95% CI (2.2, 7.2)] and 8.1% [95% CI (4.6, 12.8)], while the cumulative incidences of non-SCCs at 10 and 15 years were 5.4% [95% CI (3.1, 8.7)] and 6.9% [95% CI (4.0, 10.8)]. Antithymocyte globulin (ATG) was associated with reduced incidences of SCCs but not of non-SCCs. Patients with grade II-IV aGVHD had increased rates of SCCs after adjusting with patient age and ATG, while patients with cGVHD showed only a trend for increased rates of SCCs.
Conclusion
The data indicate that aGVHD and cGVHD affect the rates of secondary SCCs. While the use of ATG is associated with lower incidences of SCCs via reduction of GVHD, there was no association of ATG with non-SCCs.

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Metadata last modified: 16 Jan 2025 15:00

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