Induced Attenuation of Scleral TGF-β Signaling in Mutant Mice Increases Susceptibility to IOP-Induced Optic Nerve Damage

URN to cite this document:: urn:nbn:de:bvb:355-epub-581653
DOI to cite this document:: 10.5283/epub.58165

Gebert, Magdalena ; Heimbucher, Johanna ; Gsell, Valentina K. ; Keimer, Kristof ; Dillinger, Andrea E. ; Tamm, Ernst R.

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 24 Apr 2024 12:01

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Purpose: Axonal optic nerve (ON) damage in glaucoma is characteristically associated with increased amounts of active transforming growth factor-beta 2 (TGF-β2) in the ON head. Here we investigated the functional role of scleral TGF-β signaling in glaucoma. Methods: A deficiency of Tgfbr2, which encodes for TGF-β receptor type II (TGF-βRII), the essential receptor for canonical TGF-β ...