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Induced Attenuation of Scleral TGF-β Signaling in Mutant Mice Increases Susceptibility to IOP-Induced Optic Nerve Damage

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Gebert, Magdalena ; Heimbucher, Johanna ; Gsell, Valentina K. ; Keimer, Kristof ; Dillinger, Andrea E. ; Tamm, Ernst R.
Date of publication of this fulltext: 24 Apr 2024 12:01


Purpose: Axonal optic nerve (ON) damage in glaucoma is characteristically associated with increased amounts of active transforming growth factor-beta 2 (TGF-β2) in the ON head. Here we investigated the functional role of scleral TGF-β signaling in glaucoma. Methods: A deficiency of Tgfbr2, which encodes for TGF-β receptor type II (TGF-βRII), the essential receptor for canonical TGF-β ...


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