HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

URN to cite this document:: urn:nbn:de:bvb:355-epub-581716
DOI to cite this document:: 10.5283/epub.58171

Welters, Carlotta ; Welters, Marthe-Lina ; Stadler, Serena ; Bullinger, Lars ; Strobel, Julian ; Hackstein, Holger ; Dhamodaran, Arunraj ; Blankenstein, Thomas ; Hansmann, Leo

License: Creative Commons Attribution Non-commercial 4.0
PDF - Published Version
(4MB)

Date of publication of this fulltext: 26 Apr 2024 09:26

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

The null allele HLA-C*04:09N differs from HLA-C*04:01 in a frameshift mutation within its cytoplasmic domain, resulting in translation of 32 additional amino acids that are assumed to prevent cell surface expression. However, we recently identified a multiple myeloma-reactive T-cell receptor (TCR) that appeared to recognize antigen presented on HLA-C*04:09N and encouraged us to ask whether ...