Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-583342
DOI to cite this document:: 10.5283/epub.58334

Bauswein, Markus

; Eid, Ehab ; Eidenschink, Lisa ; Schmidt, Barbara

; Gessner, André

; Tappe, Dennis ; Cadar, Daniel ; Böhmer, Merle M. ; Jockel, Laura ; van Wickeren, Nora ; Garibashvili, Tamara ; Wiesinger, Isabel

; Wendl, Christina ; Heckmann, Josef G. ; Angstwurm, Klemens

; Freyer, Martin

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 May 2024 07:59

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Abstract

Background Within endemic regions in southern and eastern Germany, Borna disease virus 1 (BoDV-1) causes rare zoonotic spill-over infections in humans, leading to encephalitis with a high case-fatality risk. So far, intra-vitam diagnosis has mainly been based on RT-qPCR from cerebrospinal fluid (CSF) and serology, both being associated with diagnostic challenges. Whilst low RNA copy numbers in ...