Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response

URN to cite this document:: urn:nbn:de:bvb:355-epub-583822
DOI to cite this document:: 10.5283/epub.58382

Bülow, Sigrid

; Ederer, Katharina U. ; Holzinger, Jonas M. ; Zeller, Lisa ; Werner, Maren ; Toelge, Martina ; Pfab, Christina ; Hirsch, Sarah ; Göpferich, Franziska ; Hiergeist, Andreas

; Berberich-Siebelt, Friederike ; Gessner, André

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 03 Jun 2024 15:51

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Abstract

Neutrophil-derived bactericidal/permeability-increasing protein (BPI) is known for its bactericidal activity against gram-negative bacteria and neutralization of lipopolysaccharide. Here, we define BPI as a potent activator of murine dendritic cells (DCs). As shown in GM-CSF-cultured, bone-marrow-derived cells (BMDCs), BPI induces a distinct stimulation profile including IL-2, IL-6, and tumor ...