Intoduction: Identification of specific metabolome and lipidome profile of
patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis,
targeted personalized therapy, and more accurate risk stratification.
Methods: Nuclear magnetic resonance (NMR) spectroscopy revealed an
altered metabolome and lipidome of 33 patients with PSC [24 patients with
inflammatory bowel disease (IBD) and 9 patients without IBD] compared with
40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as
well as 64 patients with IBD and other extraintestinal manifestations (EIM) but
without PSC.
Results: In particular, higher concentrations of pyruvic acid and several
lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical
relevance, a specific amino acid and lipid profile was determined in PSC
compared with IBD and other EIM.
Discussion: These results have the potential to improve diagnosis by
differentiating PSC patients from HC and those with IBD and EIM.