CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model

URN to cite this document:: urn:nbn:de:bvb:355-epub-585441
DOI to cite this document:: 10.5283/epub.58544

Hegner, Philipp

; Ofner, Florian ; Schaner, Benedikt ; Gugg, Mathias ; Trum, Maximilian

; Lauerer, Anna-Maria ; Maier, Lars Siegfried

; Arzt, Michael

; Lebek, Simon

; Wagner, Stefan

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Jun 2024 08:55

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Abstract

Background: Obstructive sleep apnea (OSA) has been linked to various pathologies, including arrhythmias such as atrial fibrillation. Specific treatment options for OSA are mainly limited to symptomatic approaches. We previously showed that increased production of reactive oxygen species (ROS) stimulates late sodium current through the voltage-dependent Na+ channels via Ca2+/calmodulin-dependent ...