Unraveling the Role of Reactive Oxygen Species in T Lymphocyte Signaling

URN to cite this document:: urn:nbn:de:bvb:355-epub-585498
DOI to cite this document:: 10.5283/epub.58549

Gülow, Karsten ; Tümen, Deniz ; Heumann, Philipp ; Schmid, Stephan

; Kandulski, Arne ; Müller, Martina ; Kunst, Claudia

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Jun 2024 16:02

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Abstract

Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized and transient effects are due to their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I and III of the electron transport chain (ETC). Subsequent ROS production triggers the activation ...