Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity - University of Regensburg Publication Server

URN to cite this document:: urn:nbn:de:bvb:355-epub-585513
DOI to cite this document:: 10.5283/epub.58551

Brunner, Sarah ; Höring, Marcus

; Liebisch, Gerhard

; Schweizer, Sabine ; Scheiber, Josef ; Giansanti, Piero ; Hidrobo, Maria ; Hermeling, Sven ; Oeckl, Josef ; Prudente de Mello, Natalia ; Perocchi, Fabiana ; Seeliger, Claudine ; Strohmeyer, Akim ; Klingenspor, Martin ; Plagge, Johannes

; Küster, Bernhard ; Burkhardt, Ralph

; Janssen, Klaus-Peter ; Ecker, Josef

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Jun 2024 17:16

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Abstract

Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by ...