Surgical cytoreduction and hyperthermic intrathoracic chemotherapy for thymic tumours with pleural spread is effective on survival: results from the multicentre German hyperthermic intrathoracic chemotherapy study

URN to cite this document:

urn:nbn:de:bvb:355-epub-586090 Copy

DOI to cite this document:

10.5283/epub.58609 Copy

Ried, Michael ; Hassan, Mohamed ; Passlick, Bernward ; Schmid, Severin ; Markowiak, Till ; Müller, Karolina ; Huppertz, Gunnar ; Koller, Michael ; Winter, Hauke ; Klotz, Laura V. ; Hatz, Rudolf ; Kovács, Julia ; Zimmermann, Julia ; Hofmann, Hans-Stefan ; Eichhorn, Martin E.

License: Creative Commons Attribution 4.0 PDF - Published Version (958kB)

Date of publication of this fulltext: 04 Jul 2024 10:30

---

Alternative links to fulltext:DOIPublisher

---

---

Details

Item type:	Article
Open Access Type:	Gold (with APC)
Journal or Publication Title:	Interdisciplinary CardioVascular and Thoracic Surgery
Publisher:	OUP
Volume:	36
Number of Issue or Book Chapter:	6
Date:	10 February 2023
Institutions:	Medicine > Abteilung für Thoraxchirurgie
Identification Number:	Value Type 10.1093/icvts/ivad032 DOI
Keywords:	Hyperthermic intrathoracic chemotherapy • Hyperthermic intrathoracic chemotherapy • Thymic tumour • Thymic carcinoma • Cytoreductive surgery
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	58609

Preview

Export bibliographical data

ASCII CitationAtomBibTeXData Cite XMLDataCite XML OAIDublin CoreDublin Core (LZV)EndNoteHTML CitationJSONJSON LDMETSMODSOPENAIREOpenAPCRDF+N-TriplesRDF+N3RDF+XMLReferReference ManagerSimple MetadataXMLopenCostxMetaDissPlus

---

Abstract

OBJECTIVES Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITOC) is effective on survival for patients with pleural metastatic thymic tumours. METHODS Multicentre, retrospective analysis of patients with stage IVa thymic tumours treated with surgical resection and HITOC. Primary end point was overall survival, secondary end points were recurrence-/progression-free ...

Abstract

OBJECTIVES

Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITOC) is effective on survival for patients with pleural metastatic thymic tumours.
METHODS

Multicentre, retrospective analysis of patients with stage IVa thymic tumours treated with surgical resection and HITOC. Primary end point was overall survival, secondary end points were recurrence-/progression-free survival and morbidity/mortality.
RESULTS

A total of n = 58 patients (thymoma, n = 42; thymic carcinoma, n = 15; atypical carcinoid of the thymus, n = 1) were included, who had primary pleural metastases (n = 50; 86%) or pleural recurrence (n = 8; 14%). Lung-preserving resection (n = 56; 97%) was the preferred approach. Macroscopically complete tumour resection was achieved in n = 49 patients (85%). HITOC was performed with cisplatin alone (n = 38; 66%) or in combination with doxorubicin (n = 20; 34%). Almost half of the patients (n = 28; 48%) received high-dose cisplatin > 125 mg/m2 body surface area. Surgical revision was required in 8 (14%) patients. In-hospital mortality rate was 2%. During follow-up, tumour recurrence/progression was evident in n = 31 (53%) patients. Median follow-up time was 59 months. The 1-, 3- and 5-year survival rates were 95%, 83% and 77%, respectively. Recurrence/progression-free survival rates were 89%, 54% and 44%, respectively. Patients with thymoma had significantly better survival compared to patients with thymic carcinoma (P-value ≤0.001).
CONCLUSIONS

Promising survival rates in patients with pleural metastatic stage IVa in thymoma (94%) and even in thymic carcinoma (41%) were achieved. Surgical resection and HITOC is safe and effective for treatment of patients with pleural metastatic thymic tumours stage IVa.

---

---

Metadata last modified: 04 Jul 2024 10:34

Owner only: item control page

Download Statistics

Download Statistics

Download Statistics

Download Statistics

Downloads

Downloads per month over past year

Altmetric

Altmetric

Altmetric

Alternative Statistics (altmetrics)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)