Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution

URN to cite this document:: urn:nbn:de:bvb:355-epub-586306
DOI to cite this document:: 10.5283/epub.58630

Kollmar, Martin ; Welz, Tobias ; Ravi, Aishwarya ; Kaufmann, Thomas ; Alzahofi, Noura ; Hatje, Klas ; Alghamdi, Asmahan ; Kim, Jiyu ; Briggs, Deborah A. ; Samol-Wolf, Annette ; Pylypenko, Olena ; Hume, Alistair N. ; Burkhardt, Pawel ; Faix, Jan ; Kerkhoff, Eugen

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Date of publication of this fulltext: 13 Jul 2024 09:14

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Abstract

An important question in cell biology is how cytoskeletal proteins evolved and drove the development of novel structures and functions. Here we address the origin of SPIRE actin nucleators. Mammalian SPIREs work with RAB GTPases, formin (FMN)-subgroup actin assembly proteins and class-5 myosin (MYO5) motors to transport organelles along actin filaments towards the cell membrane. However, the ...