Consequences of Amyloid‐β Deficiency for the Liver

URN to cite this document:: urn:nbn:de:bvb:355-epub-588689
DOI to cite this document:: 10.5283/epub.58868

Buniatian, Gayane Hrachia ; Schwinghammer, Ute ; Tremmel, Roman

; Cynis, Holger ; Weiss, Thomas S.

; Weiskirchen, Ralf

; Lauschke, Volker M. ; Youhanna, Sonia ; Ramos, Isbaal ; Valcarcel, Maria ; Seferyan, Torgom ; Rahfeld, Jens‐Ulrich ; Rieckmann, Vera ; Klein, Kathrin ; Buadze, Marine ; Weber, Victoria ; Kolak, Valentina ; Gebhardt, Rolf ; Friedman, Scott L.

; Müller, Ulrike C. ; Schwab, Matthias ; Danielyan, Lusine

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Aug 2024 09:03

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Abstract

Abstract The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti-Aβ therapies for Alzheimer's disease (AD). Here, it is shown that partial hepatic loss of Aβ in transgenic AD mice immunized with Aβ ...