The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects

URN to cite this document:: urn:nbn:de:bvb:355-epub-588708
DOI to cite this document:: 10.5283/epub.58870

Dropmann, Anne ; Alex, Sophie ; Schorn, Katharina ; Tong, Chenhao ; Caccamo, Tiziana ; Godoy, Patricio ; Ilkavets, Iryna ; Liebe, Roman ; Gonzalez, Daniela ; Hengstler, Jan G. ; Piiper, Albrecht ; Quagliata, Luca ; Matter, Matthias S. ; Waidmann, Oliver ; Finkelmeier, Fabian ; Feng, Teng ; Weiss, Thomas S.

; Rahbari, Nuh ; Birgin, Emrullah ; Rasbach, Erik ; Roessler, Stephanie

; Breuhahn, Kai ; Tóth, Marcell ; Ebert, Matthias P. ; Dooley, Steven ; Hammad, Seddik ; Meindl-Beinker, Nadja M.

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 13 Aug 2024 09:17

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Abstract

Abstract Introduction WNT1-inducible signalling pathway protein 1 (WISP1) promotes progression of several tumor entities often correlating with worse prognosis. Here its expression regulation and role in the progression of chronic liver diseases (CLD) was investigated. Methods WISP1 expression was analyzed in human HCC datasets, in biopsies and serum samples and an HCC patient tissue ...