Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-588807
DOI to cite this document:: 10.5283/epub.58880

Godoy, Patricio ; Schmidt-Heck, Wolfgang ; Natarajan, Karthick ; Lucendo-Villarin, Baltasar ; Szkolnicka, Dagmara ; Asplund, Annika ; Björquist, Petter ; Widera, Agata ; Stöber, Regina ; Campos, Gisela ; Hammad, Seddik

; Sachinidis, Agapios ; Chaudhari, Umesh ; Damm, Georg ; Weiss, Thomas S.

; Nüssler, Andreas ; Synnergren, Jane

; Edlund, Karolina ; Küppers-Munther, Barbara ; Hay, David C. ; Hengstler, Jan G.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Aug 2024 12:36

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Abstract

Background & Aims: The differentiation of stem cells to hepatocyte-like cells (HLC) offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of HLC remains controversial. To obtain an unbiased characterization, we performed a transcriptomic study with HLC derived from human embryonic and induced stem cells (ESC, hiPSC) from three different ...