Feng, Teng ; Dzieran, Johanna ; Gu, Xing ; Marhenke, Silke ; Vogel, Arndt ; Machida, Keigo 
; Weiss, Thomas S. ; Ruemmele, Petra ; Kollmar, Otto ; Hoffmann, Patrick ; Grässer, Friedrich ; Allgayer, Heike ; Fabian, Jasmin ; Weng, Hong Lei ; Teufel, Andreas ; Maass, Thorsten ; Meyer, Christoph ; Lehmann, Ulrich ; Zhu, Cheng ; Mertens, Peter R. ; Gao, Chun Fang ; Dooley, Steven ; Meindl-Beinker, Nadja M.
; Weiss, Thomas S. ; Ruemmele, Petra ; Kollmar, Otto ; Hoffmann, Patrick ; Grässer, Friedrich ; Allgayer, Heike ; Fabian, Jasmin ; Weng, Hong Lei ; Teufel, Andreas ; Maass, Thorsten ; Meyer, Christoph ; Lehmann, Ulrich ; Zhu, Cheng ; Mertens, Peter R. ; Gao, Chun Fang ; Dooley, Steven ; Meindl-Beinker, Nadja M. 
Abstract
Transforming growth factor beta (TGF-beta) is cytostatic towards damage-induced compensatory hepatocyte proliferation. This function is frequently lost during hepatocarcinogenesis, thereby switching the TGF-beta role from tumour suppressor to tumour promoter. In the present study, we investigate Smad7 overexpression as a pathophysiological mechanism for cytostatic TGF-beta inhibition in liver ...
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