Effects of atorvastatin metabolites on induction of drug‐metabolizing enzymes and membrane transporters through human pregnane X receptor

URN to cite this document:: urn:nbn:de:bvb:355-epub-589075
DOI to cite this document:: 10.5283/epub.58907

Hoffart, E. ; Ghebreghiorghis, L. ; Nussler, A. K. ; Thasler, W. E. ; Weiss, Thomas S.

; Schwab, M. ; Burk, O.

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Date of publication of this fulltext: 16 Aug 2024 07:48

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Abstract

BACKGROUND AND PURPOSE Atorvastatin metabolites differ in their potential for drug interaction because of differential inhibition of drug-metabolizing enzymes and transporters. We here investigate whether they exert differential effects on the induction of these genes via activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR). EXPERIMENTAL APPROACH Ligand binding to ...