Extracellular factors and immunosuppressive drugs influencing insulin secretion of murine islets

URN to cite this document:: urn:nbn:de:bvb:355-epub-589087
DOI to cite this document:: 10.5283/epub.58908

Auer, V. J. ; Janas, E. ; Ninichuk, V. ; Eppler, E. ; Weiss, Thomas S.

; Kirchner, S. ; Otto, A. M. ; Stangl, M. J.

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 16 Aug 2024 09:16

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Abstract

Summary Approximately 60% of transplanted islets undergo apoptosis within the first week post-transplantation into the liver attributed to poor engraftment, immune rejection and toxicity of immunosuppressive drugs. Understanding how extracellular matrix (ECM) components, immunosuppressive drugs and proinflammatory cytokines affect insulin secretion will contribute to an improved clinical ...