Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

URN to cite this document:: urn:nbn:de:bvb:355-epub-589106
DOI to cite this document:: 10.5283/epub.58910

Schulze, Andreas ; Mills, Kerry ; Weiss, Thomas S.

; Urban, Stephan

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 16 Aug 2024 09:28

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Abstract

Human hepatitis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism. Within the liver, HBV replication occurs in differentiated and polarized hepatocytes. Accordingly, the in vitro HBV infection of primary human hepatocytes (PHHs) and the human hepatoma cell line, HepaRG, is restricted to differentiated, hepatocyte-like cells. Though preparations of PHH ...