Combined logical and data-driven models for linking signalling pathways to cellular response

URN to cite this document:: urn:nbn:de:bvb:355-epub-589160
DOI to cite this document:: 10.5283/epub.58916

Melas, Ioannis N ; Mitsos, Alexander ; Messinis, Dimitris E ; Weiss, Thomas S.

; Alexopoulos, Leonidas G

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Aug 2024 10:44

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Abstract

Abstract Background Signalling pathways are the cornerstone on understanding cell function and predicting cell behavior. Recently, logical models of canonical pathways have been optimised with high-throughput phosphoproteomic data to construct cell-type specific pathways. However, less is known on how signalling pathways can be linked to a cellular response such as cell growth, death, ...