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Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes

Wanninger, Josef ; Neumeier, Markus ; Hellerbrand, Claus ; Schacherer, Doris ; Bauer, Sabrina ; Weiss, Thomas S. ; Huber, Hanna ; Schäffler, Andreas ; Aslanidis, Charalampos ; Schölmerich, Jürgen ; Buechler, Christa




Abstract

Fatty liver is commonly detected in obesity and has been identified as a risk factor for the progression of hepatic fibrosis in a wide range of liver diseases. Transforming growth factor beta (TGF beta) and activin A. both members of the TGF beta superfamiliy, are central regulators in liver fibrosis and regeneration, and the effect of hepatocyte lipid accumulation on the release of these ...

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