Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses

URN to cite this document:: urn:nbn:de:bvb:355-epub-589383
DOI to cite this document:: 10.5283/epub.58938

Lauer, Ulrich M. ; Weiss, Thomas S.

; Bitzer, Michael ; Gregor, Michael ; Königsrainer, Alfred ; Groothuis, Geny M. M. ; Rots, Marianne ; Wehrmann, Manfred ; Wagner, Silvia ; Kupka, Susan ; Smirnow, Irina ; Armeanu-Ebinger, Sorin ; Zimmermann, Martina

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Date of publication of this fulltext: 19 Aug 2024 12:47

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Abstract

Abstract Availability of an individualized preselection of oncolytic viruses to be used for virotherapy of tumor patients would be of great help. Using primary liver tumor resection specimens we evaluated the precision-cut liver slice (PCLS) technology as a novel in vitro test system for characterization of paramount tumor infection parameters of individual patients. PCLS slices from resection ...