Insulin Decreases Inflammatory Signal Transcription Factor Expression in Primary Human Liver Cells after LPS Challenge

URN to cite this document:: urn:nbn:de:bvb:355-epub-589439
DOI to cite this document:: 10.5283/epub.58943

Jeschke, Marc G. ; Klein, Dagmar ; Thasler, Wolfgang E. ; Bolder, Ulrich ; Schlitt, Hans-Jürgen ; Jauch, Karl-Walter ; Weiss, Thomas S.

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Date of publication of this fulltext: 19 Aug 2024 13:57

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Abstract

Abstract Hepatic homeostasis is essential for survival in critically ill and burned patients. Insulin administration improves survival and decreases infections in these patients. To determine the molecular mechanisms, the aim of the present study was to establish a stress model using primary human hepatocytes (PHHs) and to study the effects of insulin on the hepatic inflammatory signaling ...