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Metformin reduces cellular lysophosphatidylcholine and thereby may lower apolipoprotein B secretion in primary human hepatocytes

Wanninger, Josef ; Neumeier, Markus ; Weigert, Johanna ; Liebisch, Gerhard ; Weiss, Thomas S. ; Schäffler, Andreas ; Aslanidis, Charalampos ; Schmitz, Gerd ; Schölmerich, Jürgen ; Buechler, Christa




Abstract

Abstract The biguanide metformin is an oral antihyperglycemic drug for the treatment of type 2 diabetes mellitus. Further, a moderate improvement of dyslipidemia by metformin was reported, and therefore, the effect of metformin on the release of apolipoprotein B (ApoB) and ApoE in primary human hepatocytes was determined. Metformin at 0.5 and 1 mM reduced hepatic ApoB secretion but ApoE was ...

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