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PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

Mühlbauer, Marcus ; Fleck, Martin ; Schütz, Christian ; Weiss, Thomas S. ; Froh, Matthias ; Blank, Christian ; Schölmerich, Jürgen ; Hellerbrand, Claus




Abstract

Background/Aims B7-H1 (PD-L1) is a B7-family member that binds to programmed death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in accelerated hepatocyte damage in experimental autoimmune hepatitis, and PD-L1 was suggested to play a critical role in regulating T cell homeostasis. Absence of PD-1 enhanced proliferation of T cells in adenovirus-infected livers and ...

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