Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-589726
DOI to cite this document:: 10.5283/epub.58972

Schuierer, Marion M. ; Bataille, Frauke ; Weiss, Thomas S.

; Hellerbrand, Claus

; Bosserhoff, Anja

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Aug 2024 12:46

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Abstract

Abstract The Ras/Raf/MEK/ERK signalling cascade is frequently deregulated in tumourigenic diseases and known to be involved in proliferation and transformation of cells. Also in hepatocellular carcinoma (HCC) increased ERK levels are observed and known to correlate with tumour progression, but the underlying molecular mechanism are unknown. We analyzed expression of Raf-1 kinase inhibitory ...