A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-589908
DOI to cite this document:: 10.5283/epub.58990

Mühlbauer, Marcus ; Bosserhoff, Anja K. ; Hartmann, Arndt ; Thasler, Wolfgang E. ; Weiss, Thomas S.

; Herfarth, Hans ; Lock, Guntram ; Schölmerich, Jürgen ; Hellerbrand, Claus

License: Creative Commons Attribution Non-commercial 4.0
PDF - Published Version
(215kB)

Date of publication of this fulltext: 26 Aug 2024 06:50

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Abstract Background & Aims: Factors influencing the progression of chronic hepatitis C virus (HCV) infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent chemokine, and its hepatic expression is up-regulated during chronic HCV infection mainly in activated hepatic stellate cells (HSC). In this study, we investigated the correlation of the functional −2518 MCP-1 ...