Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF

URN to cite this document:: urn:nbn:de:bvb:355-epub-590286
DOI to cite this document:: 10.5283/epub.59028

Goetz, Wolfgang A. ; Yao, Jiang ; Brener, Michael ; Puri, Rishi ; Swaans, Martin ; Schopka, Simon

; Wiesner, Sigrid ; Creutzenberg, Marcus ; Sievert, Horst ; Kassab, Ghassan S.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Aug 2024 13:38

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Abstract

Left ventricular (LV) longitudinal function is mechanically coupled to the elasticity of the ascending aorta (AA). The pathophysiologic link between a stiff AA and reduced longitudinal strain and the subsequent deterioration in longitudinal LV systolic function is likely relevant in heart failure with preserved ejection fraction (HFpEF). The proposed therapeutic effect of freeing the LV apex ...