Gas6 in chronic liver disease—a novel blood-based biomarker for liver fibrosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-590514
DOI to cite this document:: 10.5283/epub.59051

Staufer, Katharina ; Huber, Heidemarie ; Zessner-Spitzenberg, Jasmin ; Stauber, Rudolf ; Finkenstedt, Armin ; Bantel, Heike ; Weiss, Thomas S.

; Huber, Markus A.

; Starlinger, Patrick ; Gruenberger, Thomas ; Reiberger, Thomas ; Sebens, Susanne ; McIntyre, Gail ; Tabibiazar, Ray ; Giaccia, Amato ; Zoller, Heinz ; Trauner, Michael ; Mikulits, Wolfgang

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Date of publication of this fulltext: 03 Sep 2024 13:42

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Abstract

Abstract The expression of the receptor tyrosine kinase Axl and its cleavage product soluble Axl (sAxl) is increased in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In this multicenter study, we evaluated the diagnostic value of Gas6, the high-affinity ligand of Axl, in patients with chronic liver disease. Levels of sAxl and Gas6, and their albumin (alb) ratios were analyzed ...