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Expression of the plasma membrane citrate carrier (pmCiC) in human cancerous tissues—correlation with tumour aggressiveness

URN to cite this document:
urn:nbn:de:bvb:355-epub-591148
DOI to cite this document:
10.5283/epub.59114
Schwertner, Barbara ; Dahdal, George ; Jagla, Wolfgang ; Grossmann, Luis ; Drexler, Konstantin ; Krahn, Michael P. ; Evert, Katja ; Berneburg, Mark ; Haferkamp, Sebastian ; Ziegler, Christine ; Parkinson, Eric K. ; Zahn, Grit ; Mycielska, Maria E. ; Gaumann, Andreas
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
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Date of publication of this fulltext: 06 Sep 2024 12:27



Abstract

We have recently shown that cancer cells of various origins take up extracellular citrate through the plasma membrane citrate carrier (pmCiC), a specific plasma membrane citrate transporter. Extracellular citrate is required to support cancer cell metabolism, in particular fatty acid synthesis, mitochondrial activity, protein synthesis and histone acetylation. In addition, cancer cells tend ...

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